Safety and Pharmacokinetics of ASA404 When Given Together With Fluvoxamine, a Selective Serotonin Receptor Reuptake Inhibitor and CYP1A2 Inhibitor

A Multi-center, Open-label, Drug-drug Interaction Study to Assess the Effects of Fluvoxamine on the Pharmacokinetics of ASA404 in Adult Patients With Solid Tumor Malignancies

Status

Terminated

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01299415

Enrollment

Registered

2011-02-18

Start date

2009-08-31

Completion date

Unknown

Last updated

2011-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Solid Tumors

Keywords

ASA404,, Phase I,, Oncology,, CYP1A2,, fluvoxamine,, drug drug interaction,, Novartis,, Antisoma

Brief summary

This trial is designed to study the drug-drug interaction between ASA404 and fluvoxamine, an inhibitor of its metabolic pathway (CYP1A2). The study will consist of two phases. The purpose of the Core Phase is to study the drug drug interaction between fluvoxamine and ASA404. The purpose of the Extension Phase is to provide continued treatment for those patients that have not progressed during the Core Phase and to collect safety data on ASA404 when given in combination with paclitaxel, docetaxel or the paclitaxel plus carboplatin chemotherapy regimen.

Interventions

DRUGVadimezan™

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients having a histologically-proven and radiologically-confirmed advanced or metastatic solid tumor. 2. WHO Performance Status of 0-2. 3. A minimum of 4 weeks must have elapsed since the last treatment with other cancer therapies. 4. Laboratory values within the ranges, as defined below: * ANC ≥ 1.5 X 109 /L * Platelets ≥ 100 X 109 /L * Hemoglobin ≥ 10 g/dL * Serum total bilirubin is within normal range

Exclusion criteria

1. Patients having CNS metastasis or evidence of leptomeningeal disease. 2. Patients with any of the following: * any clinical or electrocardiographic evidence of cadiac ischemia * poorly controlled hypertension * family history of unexplained sudden death * long QT syndrome * history of ventricular fibrillation or torsade de pointes * congestive heart failure (NYHA class III or IV) * myocardial infarction within 12 months of starting study treatment 3. History of neuroendocrine tumors (e.g. carcinoid tumor, pancreatic islet cell tumor). 4. Significant neurological or psychiatric disorder. 5. Smokers (use of cigarettes within the last 3 months). 6. Concomitant use of drugs that are associated with QTc interval prolongation or have a risk of causing torsade de pointes. 7. Concomitant use of serotonin reuptake inhibitors (SSRIs), 5-hydroxytryptamine (5-HT) receptor agonists or selective serotonin / nor-epinephrine reuptake inhibitors (SNRIs) within 30 days prior to starting study treatment. 8. Concomitant use of somatostain analogues (i.e. octreotide, lanreotide within 30 days prior to starting study treatment. Other protocol-defined inclusion/

Design outcomes

Primary

Measure	Time frame
evaluate the effect of administration of fluvoxamine, a CYP1A2 inhibitor, after 2-cycles of ASA404, on the pharmacokinetics of ASA404	approximately 2 months

Secondary

Measure	Time frame
evaluate the effect of administration of fluvoxamine on the safety profile (incidence of AEs or SAEs generated) of ASA404	4 months
assess the safety (incidence of AEs and SAEs) of ASA404 in combination with paclitaxel, doctaxel or the paclitaxel plus carboplatin chemotherapy regimen in patients with solid tumor malignancies	12 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026