Retinal Detachment
Conditions
Brief summary
This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened . Process of degeneration begins from first hours of RD (Retinal Detachment) establishment Neuroprotection of photoreceptor following RD is a novel and debatable discussion encountered in recent years . How to stop this phenomena and neuroprotective agent role in this issue are a new interest of researcher. In the study the investigators are planning to perform a clinical trial to demonstrate the minocycline neuroprotective effect in a double blind design as this impact has been implicated previously in a animal study
Interventions
DRUGplacebo
100mg,BD, fo three month
DRUGMinocycline
100mg
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
8 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age over 8 years old * gender of both sex * normal liver and renal function * informed consent received from all patients * no pregnancy and no lactation * minimal sun exposure
Exclusion criteria
* old RD * diabetic retina * previous retinal surgery CRF& liver disfunction RD + PVR \> B Hyper sensitivity to tetracycline History previous MPC or PRP Patients unsuccessful SB (retina is off )
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BCVA | changes of BCVA in 3 month | outcome method of measurement: Snellen chart |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| finding of ERG changes | 3 months | outcome method of measurement: ERG( testes) |
| finding of OCT changes | 3 months | outcome method of measurement: OCT |
| finding of FAF changes | 3 months | outcome method of measurement: FAF( testes) |
Countries
Iran
Outcome results
None listed