Urinary Bladder Neurogenic Dysfunction
Conditions
Keywords
neurogenic detrusor overactivity, detrusor sphincter dyssynergia, compliance, video urodynamic, spinal cord injury
Brief summary
Most patients with spinal cord injury suffer from bladder dysfunction which may - especially in the long-term - impair renal function. Improved treatment during the last decades improved life expectancy and quality of life. This study evaluates the bladder function in the long-term after spinal cord injury.
Detailed description
Bladder dysfunction is a common consequence of spinal cord injury and depends on the completeness and the level of the lesion. Patients with suprasacral injury usually suffer from neurogenic detrusor overactivity mostly combined with detrusor sphincter dyssynergia. Without adequate treatment, this adverse combination puts the upper urinary tract at risk due to high intravesical pressure often causing vesico-ureteral reflux. Based on improved therapeutic options in the last decades, life expectancy and quality of life constantly increased in spinal cord injury patients. The investigators aim to evaluate the bladder function in the long-term after spinal cord injury.
Interventions
Sponsors
Balgrist University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Spinal cord injury for at least 5 years * Neurogenic lower urinary tract dysfunction * Written informed consent
Exclusion criteria
* Lower urinary tract dysfunction due to other causes than spinal cord injury
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urodynamic evaluation | 5 years after SCI, yearly thereafter (participants are followed until death) | Max. cystometric capacity, compliance, detrusor leak point pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| imaging of the upper urinary tract | 5 years after SCI, yearly thereafter (participants are followed until death) | videocystography, ultrasound |
| secondary complications | 5 years after SCI, yearly thereafter (participants are followed until death) | recurrent tract infection, deterioration of the upper urinary tract |
Countries
Switzerland
Outcome results
None listed