Leptin Signaling in Lean and Obese Humans

Leptin Signaling in Humans

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01297426

Acronym

Leptin signali

Enrollment

Registered

2011-02-16

Start date

2011-04-30

Completion date

2015-06-30

Last updated

2015-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Brief summary

Obesity does not respond to high circulating levels of the hormone leptin. This study is aiming at finding out why this happens and open new avenues for treatment of obesity.

Detailed description

Ex vivo and in vitro identification and study of leptin signaling pathways in commercially available cell lines serum/ plasma samples and discarded tissues from humans.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* men and women * ages 18 to 65 * BMI ranges between 20 and 45 kg/m2

Exclusion criteria

* subjects requiring special diets * history of illness other than obesity of diabetes * taking medications known to influence glucose metabolism * subjects with history of anaphylactic reaction or hypersensitivity to e. coli derived proteins or anesthetic agents * women who are breastfeeding, pregnant or wanting to become pregnant * subjects with bleeding dyscrasia or poor wound healing

Design outcomes

Primary

Measure	Time frame
Westerns / activation of signaling pathways (uo to two hours after treatment)	04/01/2016

Countries

United States

Outcome results