Healthy Subjects
Conditions
Keywords
calcium phosphate, vitamin d3, bone metabolism, human study
Brief summary
The study was conducted to investigate the effect of vitamin d3 alone and in combination with calcium phosphate on bone metabolism and further physiological parameters in healthy subjects. It is postulated that calcium phosphate beneficially influences the bone specific action of vitamin d3.
Interventions
DIETARY_SUPPLEMENTcalcium phosphate
20 subjects consume for 8 weeks a bread enriched with calcium phosphate \[1g calcium/d\]
DIETARY_SUPPLEMENTvitamin d
20 subjects consume for 8 weeks a bread with vitamin d3 \[10µg/d\]
DIETARY_SUPPLEMENTcalcium phosphate and vitamin d
20 subjects consume for 8 weeks a bread enriched with calcium phosphate \[1g calcium/d\] and vitamin d3 (10µg/d\]
OTHERplacebo
All participants consume two weeks before intervention a bread without calcium an vitamin d.
Sponsors
University of Jena
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy subjects
Exclusion criteria
* pregnancy, lactation * intake of dietary supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone resorption and bone formation markers in blood and urine | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| concentration of minerals in blood, stool and urine | 8 weeks |
| blood lipids | 8 weeks |
Countries
Germany
Outcome results
None listed