The Clinical Significance of the Uncinate Process Histopathology in Chronic Rhinosinusitis

New Insights on the Clinical Significance of the Uncinate Process Histopathology in Patients With Chronic Rhinosinusitis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01296919

Enrollment

Registered

2011-02-16

Start date

2010-03-31

Completion date

2011-12-31

Last updated

2011-09-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinosinusitis

Keywords

Chronic rhinosinusitis, Histopathology, Infundibulum, Lamina propria, Uncinate process

Brief summary

Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the inflammatory process occuring in the sinuses.

Detailed description

The purpose of the present study is to gain insight into the histopathological changes of the uncinate process in patients with chronic rhinosinusitis through comparison of its mucosal and bony elements with those of the normal uncinate process without chronic inflammation (unpublished data: Gilead Berger, Ephraim Eviatar, Tatiana Kogan, Roee Landsberg).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients with chronic rhinosinusitis who: * Failed conservative medical treatment. * Stopped treatment (topical or systemic corticosteroids) at least two months before endoscopic sinus surgery. * Had a Lund-MacKay CT score of 2 and higher of 24 available.

Exclusion criteria

* Immunosuppressed patients. * Patients in whom a pathologic evaluation of the middle turbinate was necessary (e.g., suspected neoplastic disorder). * Patients with a Lund-MacKay CT score \< 2 of 24 available. * Pregnant women. * Patients who underwent prior endoscopic sinus surgery.

Countries

Israel

Outcome results