Intensive Care Unit Syndrome
Conditions
Brief summary
Abdominal Compartment Syndrome (ASC) is defined by an Intra Abdominal Hypertension (IAH) associated with a new organ failure. The occurrence of this syndrome is not well known in infants. Preterm birth is frequently associated with gastrointestinal complications, particularly Necrotizing Enterocolitis. In this pathology it is likely that the intra abdominal pressure (IAP) increases and can participate in the occurrence of organ failures. Newborn, in particular with digestive malformation as diaphragmatic hernias, gastroschisis, could themselves be suffering from this syndrome. It would be interesting to make early diagnosis in order to optimize the management of these children. This requires reliable measurements methods and standards. Intravesical Pressure (IVP) is the most reliable validated indirect method to measure intra-abdominal pressure. In order to measure the IVP, the bladder must contain a minimum of liquid. However, using inappropriate volumes could give erroneous IAP readings. The optimal amount of saline to inject in older children, determined from pressure-volume curves study is 1 ml/kg. In preterm and term infants, this volume appear extremely low (e.g. 0 8cc if taking a child to 800 g). The question that arises is whether this quantity is sufficient to obtain reliable and reproducible measurements of IVP in preterm and term.
Interventions
OTHERMeasure of intravesical pressure
For the installation of the urinary catheter, a valve connected to a pressure head is intercalated between the probe and the collecting bag. Various Intravesical pressure measurements will be conducted after injection of 0 ml/kg, 0.5 ml/kg, 1 ml/kg, 1.5 ml/kg, 2 ml/kg, 2.5 ml/kg 3 ml/kg, 3.5 ml/kg and 4 ml/kg of physiological saline.
Sponsors
Rennes University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
0 Days to 3 Months
Healthy volunteers
No
Inclusion criteria
* Preterm or term newborn admitted in paediatric intensive care unit * With an urethral catheter * Consent signed by parents
Exclusion criteria
* Weight \> 4.5 kg * Urinary tract or bladder pathology
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determinate the optimal volume of saline injection in the bladder for measuring intravesical pressure in infants, with and without digestive pathology | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Determine the normal intravesical pressure in critically ill children, with and without digestive pathology | 2 years |
Countries
France
Contacts
PRINCIPAL_INVESTIGATOROlivier Tirel
Rennes University Hospital
Outcome results
None listed