Effect of Traditional Chinese Medicine (TCM) on Embryo Implantation in In-vitro Fertilization (IVF) Patients

Status

UNKNOWN

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01296009

Enrollment

300

Registered

2011-02-15

Start date

2010-11-30

Completion date

2011-05-31

Last updated

2011-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

In Vitro Fertilization and Embryo Transfer

Keywords

embryonic implantation, endometrial receptivity, traditional Chinese medicines, in vitro fertilization-embryo transfer, pregnant rate

Brief summary

To investigate the impact of traditional Chinese medicines (TCM) on embryonic implantation in the patients who have underwent in vitro fertilization and embryo transfer, the investigators compare the pregnancy rate in traditional Chinese medicine group and control group. The hypothesis is that pregnancy rate in traditional Chinese medicine group is higher than the control group.

Detailed description

To demonstrate the impact of traditional Chinese medicine (TCM) on embryo implantation, the investigators perform a prospective randomized study on patients who have underwent in vitro fertilization and embryo transfer (IVF-ET) in the Reproductive Medical Center of the Remin Hospital Wuhan University in the next six months. These patients were randomly divided into two groups, one group was given traditional Chinese medicine, that is, ten days oral administration of Zhuyun recipe from the day after HCG injection. The second group without any treatment, and then the pregnancy rate were observed. Frozen embryo transfer for patients do the same treatment, measured indices were also the same in both groups. Our hypothesis is that Zhuyun recipe is beneficial for embryo implantation in IVF-ET patients, it can be found that pregnancy rate in traditional Chinese medicine group is higher than the control group.

Interventions

DRUGTraditional Chinese medicine(Zhuyun Recipe)

The patients undergoing IVF-ET take orally traditional Chinese medicine(Zhuyun Recipe) for ten days.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

1. aged 18-35 years old 2. undergo IVF/ICSI-ET treatment 3. undergo fresh/ frozen embryos transplantation

Exclusion criteria

1. the numbers of embryos transplantation were more than one 2. serum estradiol level \> 5000 pg/ml and progesterone level \> 9. 54 nmol/L on the day of HCG administration

Design outcomes

Primary

Measure	Time frame	Description
pregnancy rate	Six months	12 days after embryo transplantation, the investigators measured blood hCG level in the patients and its level \> 10IU/L as a biochemical pregnancy, 4 weeks after transplantation, gestational sac and the beating heart were found as clinical pregnancy.

Countries

China

Contacts

Primary ContactNan Yu, Master's degree

nny86@126.com15827012971

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026