Cardiomyopathy, Diabetic
Conditions
Keywords
type 2 diabetes, Cardiovascular diseases, coronary syndrome have abnormalities of glucidic metabolism
Brief summary
Diagnosis of diabetic cardiomyopathy is then retained, supposing a change in the coronary microcirculation linked to an endothelial dysfunction. Abnormalities of the myocardial metabolism is frequently associated. It is regrettably about a hypothesis difficult to verify with current medical techniques.This deficiency being not only harmful to the diagnosis, but also to the assessment of the efficiency of the medical treatment on the myocardial metabolism and the endothelial function. Techniques of nuclear magnetic resonance offer interesting perspectives.
Detailed description
These techniques allow in this context: 1. to quantify the myocardial blood flow at rest and after cold pressor test in a population of healthy volunteers. The myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique. 2. to estimate the metabolic and structural abnormalities in this population, with particularly: * Quantification of the myocardial metabolism in vivo by spectrometry of phosphorus 31. * Structural abnormalities: become integrated into the description of diabetic cardiomyopathy.
Interventions
OTHERNUCLEAR MAGNETIC RESONANCE IMAGING
Techniques of nuclear magnetic resonance offer interesting perspectives in this context, and particularly to quantify the myocardial blood flow at rest and after cold pressor test in a population of healthy volunteers.
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* more than 18 years old * patient type 2 diabetes affects taken care more than 5 years to Timone Hospital * patient with a diabetic cardiomyopathy * informed and consented
Exclusion criteria
* less than 18 years * Pregnant woman * patient type 1 diabetes affects * patient presents a cardiomyopathy mixed (no diabetic) * patients presents an arrhythmia ventriculaire or above - ventriculaire * Unstable hémodynamique patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To quantify the myocardial blood flow at rest and after cold pressor test in a population of healthy volunteers | 12 months | The myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To estimate the metabolic and structural abnormalities in this population | 12 months | * Quantification of the myocardial metabolism in vivo by spectrometry of phosphorus 31 which allows to estimate the energy state of the heart by analyzing the phosphorous metabolites with high energy involved in the myocardial energetic metabolism. * Structural abnormalities: evaluation of the fibrosis and the collagenic deposits by T1 mapping and measurement of relaxation T2 as well as the study of the late enhancement of gadolinium. These structural abnormalities become integrated into the description of diabetic cardiomyopathy. |
Countries
France
Contacts
Primary ContactJacques Quilici, Doctor
Outcome results
None listed