Measurement of High Order Aberrations in Late Stages Keratoconus

Feasibility of Measurement of High Order Aberrations in Late Stages Keratoconus by Using an Adaptive Optics Visual Simulator AOVIS-I

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01295164

Acronym

VOPTICA

Enrollment

Registered

2011-02-14

Start date

2011-10-31

Completion date

2012-11-30

Last updated

2017-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus

Keywords

keratoconus, wave-front sensing technology, aberrometer

Brief summary

The instrument that will be used in the study is the Murcia monocular Adaptive Optics Visual simulator (AOVIS-I). The system provides an objective characterization of the optical quality of the patient's eye by application of wave-front sensing technology. The optical condition of every eye is represented by its wave aberration. This characterization overcomes the current description based only in refractive errors. This provides an accurate description of the optics of the eye based on the assessment of the whole set of ocular aberrations. The particular wave-front sensor is of a Hartmann-Shack type. One characteristics of this wave-front sensor is its high dynamic range allowing measuring highly aberrated eyes, such as patients with keratoconus.

Detailed description

The complete procedure in one patient takes less than 5 minutes and is completely non-invasive.

Interventions

DEVICEclassic aberrometer and aberrometer AOVIS-1

Measurement of aberrations in early stages (1 and 2) of keratoconus as compared aberrometer AOVIS-1 with a classic aberrometer.

DEVICEAberrometer AOVIS-I

Measurement of aberrations in high stages (3 and 4) of keratoconus. Objective characterization of the optical quality of the patient eye by application of wave-front sensing technology in late stage keratoconus The complete procedure in one patient takes less than 5 minutes in only one consultation and is completely non invasive. The optical measurements only involve the use of low power infrared laser

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* to be able to understand an information and give a consent * patients over 18 * patients with keratoconus * affiliated to medical insurance.

Exclusion criteria

* non keratoconus patients * patients under 18 * pregnant women or nursing mothers * ocular surgery 90 days before inclusion * ocular infection * keratitis * restless patients

Design outcomes

Primary

Measure	Time frame
The primary outcome of the study is to evaluate the AOVIS-I and its wave-front sensor with high dynamic range for measuring high-order aberrations in patients with late stages (3 and 4) of keratoconus	at the 1st day

Secondary

Measure	Time frame
To evaluate the reliability of the measures in early stages (1 and 2) of keratoconus as compared with a classic aberrometer.	at the 1st day
To describe the measures obtained in advanced stages (3 and 4) of keratoconus.	at the 1st day

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026