Keloid Scar
Conditions
Keywords
scar formation, 5-FU, genetic link, psychological impact, social impact
Brief summary
To clarify the mechanisms of Keloid scar formation. Elucidate the action and therapeutic value of 5-FU in Keloid scar treatment Identify the genetic link with Keloid scar formation. Quantify the psychological/social impact in keloid scarring patients
Interventions
DRUG5- fluorouracil
5mg of 5FU injected per 1cm square, at 6 week intervals for 30 weeks = 6 sessions
RADIATIONradiotherapy
after complete excision of keloid they have a single session of radiotherapy
DRUGTriamcinolone
TAC 10mg in 1ml injected intralesional
Sponsors
Queen Mary University of London
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Adult ( \> 18 years old). * Keloid scarring present. * Able to understand and give informed consent. * Patients giving informed consent to donate keloidal or non-affected skin when that is redundant after a procedure (i.e. BBR, Abdominoplasty). * Patients with a strong familial pedigree of keloid scar formation.
Exclusion criteria
* Open wound at or proximity of the lesion * Infected lesion * Pregnant or planning pregnancy in the near future * Lactating (Breast Feeding) * Abnormal renal or liver function tests * Atrophic scars * Patient under 18 years of age * Immunocompromised * OR immunosuppressed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Keloid Scar Reduction | 18 months | Using a 3D scanner to observe the reduction of the scar volume measured in cubic centimetres |
Countries
United Kingdom
Outcome results
None listed