Chronic Kidney Disease, Vascular Calcification
Conditions
Keywords
magnesium, kidney transplantation, hypomagnesemia
Brief summary
Both Kidney transplantation (KT) and Chronic Kidney Disease (CKD) patients have reduced kidney function. Low serum magnesium is more prevalent in KT recipients. The present study examines the difference in vascular calcification between KT and CKD and its association with serum magnesium.
Detailed description
Kidney transplantation (KT) improved quality of life and longevity of CKD patients. Nevertheless, kidney function deteriorates overtime in a manner not different from CKD counterparts. Hypomagnesemia is prevalent in KT recipients secondary to immunosuppressive therapy. In addition to serum calcium, phosphate and elemental calcium intake, the relationship between low serum magnesium and vascular calcification (VC) has been observed in small studies in CKD. Whether low serum magnesium associates with VC in KT has never been elucidated. The present study compares vascular calcification between KT and CKD and its association with serum magnesium.
Interventions
None listed
Sponsors
Ramathibodi Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* kidney transplant recipients at least 1 year post surgery * predialysis chronic kidney disease with serum creatinine \> 1.1 mg/dL in female and 1.3 mg/dL in male
Exclusion criteria
* acute kidney injury * parathyroidectomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in vascular calcification score between KT and CKD | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| The association of serum magnesium with vascular calcification in KT | Baseline |
| The association of serum magnesium with vascular calcification in CKD | Baseline |
Countries
Thailand
Outcome results
None listed