Acute Pancreatitis, Pancreatitis
Conditions
Keywords
Copeptin, Vasopressin, antidiuretic hormone (ADH)
Brief summary
The purpose of this study is to investigate if there is an association between copeptin level in serum and the severity of pancreatitis and if copeptin can be used as a predictor for organ failure and pancreatic necrosis with or without superinfection.
Detailed description
Acute pancreatitis may range from mild to severe disease with high mortality in case of infected pancreatic necrosis. Due to its rising incidence it remains an important healthcare problem in Europe and US. The assessment of the severity of pancreatitis is crucial for the further management and the prognosis. Several quite complex scores like Ranson or APACHE II scores has been used in the past with reasonable sensitivity for necrosis or superinfection as well as inflammation markers like c-reactive Protein. Copeptin, the C-terminal part of antidiuretic hormone, is a relatively stable peptide in blood circulation. Several studies investigated Copeptin in the presence of Systemic Inflammatory Response Syndrome (SIRS) or sepsis, myocardial infarction, lower respiratory tract infection and cerebral stroke. Copeptin has shown to be a helpful prognostic marker in these diseases. The aim of this prospective study is to investigate whether Copeptin can be used to assess the severity of pancreatitis.
Interventions
OTHERNo intervention
No intervention
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of acute pancreatitis * written informed consent * inpatient treatment
Exclusion criteria
* time interval between onset of abdominal symptoms and study inclusion \>96h * patients unable to consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Association between copeptin level and severity of pancreatitis (according to Atlanta classification) | 48 hours | Copeptin level will be measured on admission into hospital and severity of pancreatitis will be classified according to the Atlanta criteria. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of copeptin with C reactive protein and procalcitonin in terms of assessing severity of pancreatitis | 48 hours | — |
| Predictive accuracy of copeptin, C reactive Protein (CRP) and procalcitonin in terms of developing organ failure, necrosis and/or superinfection and mortality | Duration of hospitalisation | Determinating Atlanta score, Sofa score. Assessing local complications by checking CT scan and searching for superinfection in fine needle aspiration and/or biopsy. |
| Determine whether change in copeptin level from day 0 to 2 is associated with organ failure, necrosis and/or superinfection | Duration of hospitalisation | To determine if the change in copeptin level is associated with organ failure, necrosis and superinfection |
Countries
Switzerland
Outcome results
None listed