HCV (Hepatitis C Virus) Viral and Host Genotyping (IL28B, Interleukin 28B) in China

Conditions

Hepatitis C

Keywords

HCV viral genotypes, host genotypes, IL28B, ITPA, RNA, China

Brief summary

The primary objective of this study is to estimate the distributions of HCV viral/human genotypes (including IL28B and inosine triphosphatase, ITPA), and HCV RNA level among ITPA gene among 1000 Han ethnic Chinese patients with HCV who are antiviral treatment naive at the time the study is conducted.

Detailed description

A sample of 1000 Han ethnic Chinese male or female who are ≥ 18 years old with a recent confirmation of anti-HCV-antibody positive and HCV RNA positive but antiviral treatment naive from 28 university affiliated hospital in China. The primary objective of this study is to estimate the distributions of HCV Viral genotyping(ie, genotype 1 through 6 and their known subtypes), and host genotypes, both inosine triphosphatase (ITPA) gene, and IL28B. This study also collects other data including patients' demographic and clinical characteristics. There is no active antiviral treatments and no follow-up in this study.

Nan Wu, Huiying Rao, Weibo Yang, Zhiliang Gao, Ruifeng Yang et al. (9 authors)

Chinese Medical Journal2020-01-1330 citations

10.1097/cm9.0000000000000629

A cross-sectional assessment of health-related quality of life in Chinese patients with chronic hepatitis c virus infection with EQ-5D.

Huang R, Rao H, Shang J, Chen H, Li J, Xie Q, Gao Z, Wang L, Wei J, Jiang J, Sun J, Jiang J, Wei L.

2018-06-1525 citations

10.1186/s12955-018-0941-8

Hepatitis B virus infection in Chinese patients with hepatitis C virus infection: prevalence, clinical characteristics, viral interactions and host genotypes: a nationwide cross-sectional study

Libo Yan, Huiying Rao, Yuanji Ma, Lang Bai, En‐Qiang Chen et al. (9 authors)

BMJ Open2016-10-0120 citations

10.1136/bmjopen-2016-012016

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* male or female * Han ethnic * ≥ 18 years old * recent confirmation of anti-HCV-antibody positive and HCV RNA positive 30 days prior to the recruitment * antiviral or interferon treatment naive

Exclusion criteria

* \< 18 years old * not Han ethnic * treated by antiviral before this study

Design outcomes

Primary

Measure	Time frame	Description
Hepatitis C viral and host genotypes	Confirmation of an HCV infection 30 days prior to the recruitment	To describe the distributions of both HCV viral and host genotypes (IL28B and ITPA) among antiviral treatment naive HCV patients

Secondary

Measure	Time frame	Description
Hepatitis C RNA levels	Confirmation of an HCV infection 30 days prior to the recruitment	To describe the distribution of HCV RNA levels in antiviral treatment-naive HCV patients

Countries

China

Outcome results