Morphinan Opioid Overdose
Conditions
Keywords
opioid, overdose, naloxone, intranasal
Brief summary
The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients
Detailed description
In intravenous drug abusers (IDUs), as a result of previous intravenous substance abuse, the predictable difficult cannulate exist and cause the delay administration of antidote therapy. Additionally, IDUs are also at increased risk of carrying blood borne infections that could be transmitted to healthcare workers through needle stick injuries. The investigators aimed to compare intranasal administration of naloxone with intravenous route.
Interventions
spray naloxone, 0.4 mg/ each 4 minutes till increasing patient level of consciousness
DRUGIntravenous
Amp naloxone, 0.4 mg / each 4 minutes till increasing patient level of consciousness
Sponsors
Isfahan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with the range of 15-50 years old * Who were suspicious to opioid overdoses based on history and having clinical appearance such as miotic pupils with loss of consciousness * Give response to naloxone with increasing the level of consciousness
Exclusion criteria
* Not giving response to naloxone and suspicious to have another reason for loss of consciousness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| level of consciousness | 4 min after naloxone administration | The investigators evaluated the level of consciousness with Glasgow coma sclae 4 minutes after naloxone administration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | at 4 min after naloxone administration | The investigators evaluated blood pressure 4 minutes after naloxone administration |
Countries
Iran
Outcome results
None listed