Effect of Dietary Fat on Glycemic Control in Type 1 Diabetes

Use of Closed Loop Control to Examine the Effect of Changes in Dietary Fat Intake on Insulin Requirements and Glucose Control

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01292590

Enrollment

Registered

2011-02-09

Start date

2010-09-30

Completion date

2011-09-30

Last updated

2017-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 Diabetes

Brief summary

The purpose of this study is to determine if dietary fat alters insulin requirements in type 1 diabetes.

Detailed description

This cross-over prospective study will require a two day admission to the clinical research center. Subjects will undergo closed loop glucose control and will received a diet with controlled macronutrient content.

Interventions

OTHERHigh fat meal

40 grams saturated fat

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* type 1 diabetes using insulin pump and CGM

Exclusion criteria

* renal or hepatic failure * cancer or lymphoma * malabsorption or malnourishment * hypercortisolism * alcoholism or drug abuse * anemia (hematocrit \< 36 in females and \<40 in males) * eating disorder * dietary restrictions * Acetaminophen allergy * Chronic acetaminophen use * Glucocorticoid therapy

Design outcomes

Primary

Measure	Time frame
Change in insulin requirements	postprandially until 8 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026