Triclosan Toothpaste and Third Molar Surgery

Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01292343

Enrollment

141

Registered

2011-02-09

Start date

2008-02-29

Completion date

2013-02-28

Last updated

2015-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Socket, Wound Infection

Keywords

third molars, triclosan, toothpaste, dry socket, wound infection

Brief summary

Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

Detailed description

This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

Interventions

OTHERColgate Total Toothpaste

Toothbrushing with Colgate Total Toothpaste

OTHERColgate Regular Toothpaste

Toothbrushing with Colgate regular toothpaste

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* must include at least one mandibular third molar with partial or full bony impaction * no sign of active pericoronal (around the crown) infections * must have not taken antibiotics for any reason in the past 30 days * must be healthy and between 18 and 35 years of age * must be able to read and sign an informed consent

Exclusion criteria

* Subjects with systemic diseases and pregnant or lactating women * Subjects with advanced periodontal diseases or having two or more untreated caries lesions * Subjects who cannot read and sign an informed consent * Subjects with signs of pericoronal infections

Design outcomes

Primary

Measure	Time frame	Description
dry socket	3 to 7 days	Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction

Secondary

Measure	Time frame	Description
wound infection	3 to 7 days	Development of tooth extraction wound infection 3 to 7 days after extraction

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026