Delirium, Stress Disorders, Post-Traumatic
Conditions
Keywords
Sedation, Delirium, PTSD, Depression, Anxiety, HRQoL, CAM-ICU, RASS, SF-36, ICU-memory tool, Antipsychotic Agents, Mobilization, ICU-nursing, ICU, intensive care, critical care, critical care nursing
Brief summary
The aim of this study is to investigate if sedation of Intensive Care Unit (ICU) patients influences the development of delirium during their ICU stay and if incidences of delirium have an impact on the development of Post-traumatic Stress-Disorder (PTSD). Hypothesis 1: Patients who are minimally sedated, remember staying in ICU and experiences fewer episodes of delirium than patients that are heavily sedated Hypothesis 2: Former delirious patients are more likely to develop PTSD Hypothesis 3: Delirium decreases health-related quality (HRQoL) of life after discharge
Detailed description
Background: It is known that ICU patients that experience delirium have longer hospital stay, higher mortality and morbidity. Other studies indicate that PTSD, dementia or depression may emerge after discharge from hospital. Methods according to hypothesis 1: During ICU stay: Measure sedation level & delirium. First follow-up 1-2 weeks after ICU: Memories Analyses: Data will be analyzed descriptive via EPIDATA and Stata Delirium is endpoint, defined as CAM-ICU positive. Sedation level is exposure variable. Confounders: priory antipsychotic treatment or hypertension,glasses or hearing aids,alcohol and tobacco abuse,degree of illness,age and sex. Correlation between sedation level and memories will be calculated. Methods according to hypothesis 2: Screening for: PTSD, Depression, Anxiety Analyses: PTSD is endpoint, and delirium is the exposure variable. Main confounders: Anxiety and Depression Mean of PTSD will be calculated with Confidence Interval to test any difference between experienced delirium or not. Methods according to hypothesis 3: Method:Health-related quality of life is endpoint, Activities of daily living (ADL), Memories, and a Script Test (only after 2 month) Analyses: Mean of HRQoL will be calculated with Confidence Interval to test any difference between experienced delirium or not. Confounders: Diary and/or Follow up
Interventions
None listed
Sponsors
The Novo Nordic Foundation
University of Aarhus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ICU-stay \> 48 hours
Exclusion criteria
* Severe brain trauma * Non-Danish-speaking * Age \< 18 years * Death (only hypothesis 2 and 3 in the study)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sedation level and Delirium | At least twice a day while in the ICU | Sedation assessed with RASS and delirium assessed with the CAM-ICU by the nurses at the ICU |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Post Traumatic Stress Disorder | 2 and 6 month after ICU-discharge | Minimum 250 patients who accept phone interviews are called twice (after 2 and 6 month) to answer these questionnaires: * Intensive Care Unit - memory tool * Harvard Trauma Questionnaire (HTQ) * Major Depression Inventory (MDI) * State-Trait Anxiety Inventory Form Y (STAI) |
| Health-related quality of life | 2 and 6 month after ICU-discharge | Minimum 250 patients who accept phone interviews are called twice (after 2 and 6 month) to answer the questionnaires: * Activities of daily living (ADL) * Short-form 36 * Script Test (only after 2 month) |
Countries
Denmark
Outcome results
None listed