A Study to Evaluate the Safety of Augment™ Bone Graft

Inclusion criteria

* Prior Magnetic Resonance Imaging (MRI) evaluation or MRI on Screening. * Subjects with Grade III osteochondral defect (OCD) of femoral condyle. * Subjects with OCD \> 1 cm.squared. * Independent and ambulatory pts. * Subjects from 18 to 40 years of age. * Subject with a stable knee joint and similar stability on the opposite knee. * Subject has knee x-ray with \< 15 degrees of valgus and \< 5 degrees varus. * No deformity from previous fractures of tibia or fibula. * BMI \< 35. * Subject has an American Association of Anaesthetists physical status classification of 1 or 2. * Subject must present with pain \> 3.0 cm according to the Visual Analogue Score. * Subject has exhausted non operative treatment. Exclusion: * Allergy to yeast derived products. * Index knee has had cartilage repair in the last six months. * Subjects with osteoarthritis,inflammatory arthritis, rheumatoid arthritis and avascular necrosis of index knee. * Subject has contralateral knee complications which would interfere with rehabilitation * Subject has implanted metallic devices that would prevent Magnetic Resonance Imaging (MRI). * Subject has claustrophobia that would prevent MRI. * Subject has had a malignancy or is being treated for a malignancy. * Subject is physically or mentally compromised that would interfere with compliance. * Subject is a prisoner or transient. * Subject has a recent history (12 months) of alcohol abuse. * Subject is pregnant, able to become pregnant but not practising birth control. * Subject has an infection in the operative area. * Subject has scheduled surgery on the contralateral knee over the course of the study. * Subject requires another procedure in the index knee. * Subject has had steroid therapy in the past six months. * Subject is taking prescription pain medication for another indication other than the index knee. * Subject is using nicotine in any form.