Irritable Bowel Syndrome, Lactose Intolerance
Conditions
Keywords
lactose intolerance, DNA sequencing, psychosocial factors, irritable bowel syndrome, visceral hypersensitivity
Brief summary
Lactose is a carbohydrate found in milk,and Lactase Deficiency (LD) is a condition in which the small intestine cannot digest this carbohydrate due to absent or insufficient amounts of lactase.Individuals with LD may be intolerant of lactose in the diet and experience abdominal cramps, bloating and diarrhea; however the response is variable.Some tolerate moderate amounts of lactose without adverse effect,whereas others experience severe symptoms in response to even small doses. These problems may be representative of wider issues regarding individual tolerance to diet containing ubiquitous poorly absorbed, fermentable carbohydrates (such as: fructose, fructans)and be relevant to symptom generated in patients with diarrhea predominant irritable bowel syndrome (D-IBS). This project will investigate the effects of diet,lifestyle stress and psychiatric dietary on the development of functional gastrointestinal symptoms. Lactose will be used to assess tolerance to dietary challenge, a test that is particularly relevant in a Chinese population with a high prevalence of lactase deficiency.
Detailed description
Study #1: Questionnaire study in general Chinese population (n=2000). Study #2: Physiologic study in patients attending gastroenterology clinic (n=600) including in subgroups assessment of genetic factors,tolerance to lactose challenge and assessment of visceral sensitivity. Study #3: Assessment of appropriate dosage of lactose hydrogen breath test in a population with high-prevalence of lactase deficiency. Study #4: Impact of a determined dietary intervention on abdominal symptoms compatible with D-IBS. study #5: The association of visceral sensitivity induced by LI with mucosal immune activation and psychological factors in D-IBS patients
Interventions
DIETARY_SUPPLEMENTdietary restriction
restrict intake of lactose
Sponsors
University Hospital, Zürich
Sir Run Run Shaw Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
16 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Aged at least 16 years old and not more than 75 years old. 2. Ability to communicate with the investigator, complete study questionnaires (with help of investigator) and provide informed consent.
Exclusion criteria
1. Progressive, severe disease requiring active medical management (e.g. advanced cardiac, liver, renal or neurological disease, advanced cancer) 2. History of significant gastrointestinal pathology (other than gastro-oesophageal reflux disease and functional bowel diseases) 3. History of gastro-intestinal surgery (except appendicectomy, cholecystectomy, hernia repair). 4. Evidence of active drug or alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effects of lactose intolerance on gastrointestinal function and symptoms | Three years |
Secondary
| Measure | Time frame |
|---|---|
| To measure the intake of dietary lactose in the adult general population and in patients with IBS | three years |
| To assess genetic factors, tolerance to lactose challenge and visceral sensitivity. | three years |
| To assess appropriate dosage of lactose hydrogen breath test | two years |
| To determine the impact of a determined dietary intervention on abdominal symptoms compatible with D-IBS. | three years |
| To explore the association of visceral sensitivity induced by LI with mucosal immune activation and psychological factors in D-IBS patients | two years |
Countries
China
Contacts
Primary ContactNing DAI, MD
Outcome results
None listed