Severely Obese Patients
Conditions
Keywords
severely obese patients
Brief summary
Growing evidence suggests that bariatric surgery is a relevant treatment for severely obese patients, especially those with metabolic complications, as it significantly reduces weight, hypertension and ameliorates glycemic control. Its action on adipose tissue distribution and in particular on epicardial adipose tissue EAT remains unknown. Whether metabolic improvement is associated with EAT reduction is also unknown. The researchers thus investigated the effect of bariatric surgery on EAT in severely obese patients. The primary endpoint of this study was the change in EAT amount 6 months after bariatric surgery.
Detailed description
The best of our knowledge, no study has really addressed whether this EAT was modulated by diet or therapeutics like bariatric surgery. The researchers were particularly interested in studying the impact of bariatric surgery and of weight loss on the amount of EAT and whether reduction in EAT could have a positive impact on myocardial function.
Interventions
PROCEDUREbariatric surgery
The bariatric surgery is a relevant treatment for severely obese patients those with metabolic complications, as it significantly reduces weight, hypertension and ameliorates glycemic control.
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Intervention model
CROSSOVER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* men or women who have more than 18 years * patients have been informed and have consented * severely obese patients with surgery indication
Exclusion criteria
* contraindications at surgery, at MNR imagery * History of infarct, of congenital cardiomyopathy * Treatment modifying the distribution of the fat * Pregnant or breast-feeding women * patients less than 18 years * Patient without consentment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change in EAT amount 6 months after bariatric surgery. | 36 months | We thus investigated the effect of bariatric surgery on EAT in severely obese patients. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of 3 parameters | 36 months | 1. to evaluate the variation in myocardial, hepatic , pancreatic and triglyceride content 2. to evaluate the variation in left ventricular function or myocardial function 3. and to describe the relationships between changes in visceral abdominal fat, subcutaneous fat and epicardial fat |
Countries
France
Outcome results
None listed