Chronic Urticaria
Conditions
Keywords
Chronic urticaria, Natural course, Remission
Brief summary
The purpose of this study is to examine the natural history of chronic urticaria in children and to identify the predictors for chronic urticaria remission.
Detailed description
A Prospective cohort study of 92 children who were diagnosed with chronic urticaria to investigate the natural course of chronic urticaria and to identify predictors of disease remission.
Interventions
None listed
Sponsors
Mahidol University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 15 Years
Healthy volunteers
No
Inclusion criteria
* Children 4-15 years of age with the diagnosis of chronic urticaria who were attending the pediatric allergy clinic, Siriraj Hospital Mahidol University, Thailand, from March 2003 to March 2009.
Exclusion criteria
* Children who had isolated physical urticaria, inability to be followed up, pregnancy, underlying diseases such as cardiovascular, hepatobiliary, and renal diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed. | 6 years | Remission rates at 1, 3 and 5 years after the onset of symptoms of chronic urticaria. Description in details: Actually, this study have been started in March 2003 and finally done in March 2009, which would be totally 6 years. We eventually decided to report the rate of CU remissions only at 1, 3 and 5 years after the onset of symptoms because this would be the common interval time of CU symptoms that patients needed to know how long they should have those CU symptoms or how many of them would go away their symptoms within 1, 3 or 5 years. Another reason is that the remission rate of CU between 5 and 6 years was not significantly different, so it might not need to be reported. |
Countries
Thailand
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Chronic Urticaria Chronic urticaria, Natural history | 92 |
| Total | 92 |
Baseline characteristics
| Characteristic | Chronic Urticaria |
|---|---|
| Age, Continuous | 8.4 Years |
| Region of Enrollment Thailand | 92 participants |
| Sex: Female, Male Female | 49 Participants |
| Sex: Female, Male Male | 43 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 62 / 92 |
| serious Total, serious adverse events | 0 / 92 |
Outcome results
Primary
Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed.
Remission rates at 1, 3 and 5 years after the onset of symptoms of chronic urticaria. Description in details: Actually, this study have been started in March 2003 and finally done in March 2009, which would be totally 6 years. We eventually decided to report the rate of CU remissions only at 1, 3 and 5 years after the onset of symptoms because this would be the common interval time of CU symptoms that patients needed to know how long they should have those CU symptoms or how many of them would go away their symptoms within 1, 3 or 5 years. Another reason is that the remission rate of CU between 5 and 6 years was not significantly different, so it might not need to be reported.
Time frame: 6 years
Population: Children 4-15 years old with chronic urticaria
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Chronic Urticaria | Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed. | Remission rate at 1 year after the onset | 18.5 percentage of participants |
| Chronic Urticaria | Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed. | Remission rate at 3 year after the onset | 54 percentage of participants |
| Chronic Urticaria | Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed. | Remission rate at 5 year after the onset | 67.7 percentage of participants |