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Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity

Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT01283451
Enrollment
63
Registered
2011-01-26
Start date
2010-01-31
Completion date
2016-12-31
Last updated
2018-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Compartment Syndrome

Keywords

near-infrared spectroscopy

Brief summary

Near infrared spectroscopy (NIRS) provides a non-invasive means of continuously monitoring tissue oxygenation, which may be useful for diagnosis of acute compartment syndrome (ACS). Placement of these sensor pads on the surface of the skin must be such that light penetrates the intended compartment without inadvertently obtaining measurements of an adjacent compartment. The objective of this study is to examine whether the NIRS measurements of each compartment truly represent the tissue perfusion of the intended compartment, as indicated by the predictable decrease in muscle oxygenation of a given compartment in response to muscle fatigue. The investigators hypothesize that the tissue oxygenation values of the stimulated compartment will significantly decrease following muscle stimulation, indicating that the intended muscle compartment was successfully isolated. Additionally, the investigators hypothesize that NIRS values of unstimulated muscle compartments will not change from baseline.

Interventions

BEHAVIORALMuscle contraction

Participants will perform a 30-60 second exercise designed to cause a temporary decrease in muscle oxygenation of a specific muscle group.

Sponsors

J&M Shuler
Lead SponsorINDUSTRY

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes

Inclusion criteria

* 18-75 years old * no current extremity injuries * willing to provide written informed consent

Exclusion criteria

* history of any anatomy-altering surgery to the extremity in question * history of peripheral vascular disease * history of pulmonary disease

Design outcomes

Primary

MeasureTime frameDescription
Near infrared spectroscopy<30 minutesNIRS values will be measured before and after muscle fatigue

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026