The Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Multiple Sclerosis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01280539

Enrollment

Registered

2011-01-20

Start date

2011-01-31

Completion date

2012-06-30

Last updated

2012-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis, Transcutaneous electrical nerve stimulation, Cortical Excitability

Brief summary

In this study the researchers want to investigate the effects of long-term transcutaneous electrical nerve stimulation on the cortical excitability of persons with multiple sclerosis.

Interventions

DEVICETranscutaneous electrical nerve stimulation

3 weeks, 5 times a week, 60 minutes a day.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 68 Years

Healthy volunteers

Inclusion criteria

* Expanded Disability Status Scale (EDSS) scores between 2 and 6.5 * Stable MS (no relapse during the last 3 months before study onset) * sensory impairment * age: between 18 and 68 years old

Exclusion criteria

\- Patients with other pathologies associated with peripheral and/or central sensory dysfunction or under psychotropic or antiepileptic medication

Design outcomes

Primary

Measure	Time frame	Description
Change in cortical excitability	Baseline, immediately after and 3 weeks after the intervention	Cortical excitability will be assessed using transcranial magnetic stimulation (TMS)

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026