Effect of Increased Protein Intake on Colonic Metabolism

Influence of a Protein Diet on the Colonic Metabolism and Phosphorus Housekeeping in Healthy Volunteers.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01280513

Enrollment

Registered

2011-01-20

Start date

2009-10-31

Completion date

Unknown

Last updated

2012-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Protein Fermentation, Toxicity in the Colon

Brief summary

The purpose of this study is to modulate the protein fermentation and to investigate the effect on colon toxicity.

Interventions

DIETARY_SUPPLEMENTHigh protein intake

30% of energy intake coming from proteins

DIETARY_SUPPLEMENTLow Protein intake

9% of energy intake coming from proteins

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * Regular eating pattern (3 meals/day) * Age between 18 and 45 years old * BMI between 18,5 and 30 kg/m²

Exclusion criteria

* Intake of antibiotics in the last month before the study * Abdominal surgeries in the past (accept appendectomy) * Consulting a dietician/following a diet * Vegetarian * Intake of pre- and/or probiotics * Exposure to radioactivity in the year proceeding the study

Design outcomes

Primary

Measure	Time frame
Fecal water toxicity	Participants were followed for 5 weeks, with measurements on 3 specific time points

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 24, 2026