Acute Respiratory Failure, Cardiac Surgery, Mechanical Ventilation
Conditions
Keywords
functional residual capacity, electrical impedance tomography, inflammatory parameters
Brief summary
In ventilated patients with acute respiratory failure endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. Regional distribution of ventilation can be followed at bedside using electrical impedance tomography. The investigators hypothesize that a FRC guided recruitment strategy, aimed at restoring a baseline FRC value after open endotracheal suctioning, improves oxygenation and regional distribution of ventilation. In addition the investigators research the impact of such a strategy on the inflammatory response to mechanical ventilation.
Interventions
PROCEDUREalveolar recruitment manoeuvre
Increase of airway pressures in a stepwise manner from set peak inspiratory pressure/ positive end-expiratory pressure up to 40/15 mbar and back over 2 minutes.
Sponsors
European Society of Intensive Care Medicine
University of Luebeck
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* need for mechanical ventilation due to respiratory failure after cardiac surgery
Exclusion criteria
* circulatory failure, eg. need for high doses of inotropes or extracorporal cardiac support
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regional ventilation | 6 hours | Regional distribution of ventilation over 6 hours of treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| arterial oxygenation and inflammation | 6 hours | Changes of arterial oxygenation and inflammatory parameters in the blood during 6 hours of treatment |
Countries
Germany
Contacts
Primary ContactHermann Heinze, MD
Outcome results
None listed