Type 1 Diabetes Mellitus
Conditions
Keywords
paediatric and adolescent population, nailfold capillaroscopy, laser Doppler flowmetry, retinal vessel calibre, retinal vessel fractal analysis, 24 hour Ambulatory Blood Pressure Monitoring
Brief summary
This project aimed to explore novel methods of detecting small blood vessel disease in a paediatric population with type 1 diabetes mellitus. To do this the techniques of Nailfold capillaroscopy, laser Doppler flowmetry, retinal (eye) vessel analysis and 24-hr Ambulatory Blood Pressure Monitoring were used. Each of these techniques investigated different areas of small blood vessels around the body. It was hypothesized that in a paediatric population with type 1 diabetes mellitus the novel investigations would be associated with small blood vessel disease and that widespread changes to these blood vessels would be detected through associations between the different novel investigations.
Interventions
PROCEDUREVideo Nailfold Capillaroscopy
Single session of video Nailfold Capillaroscopy wit KKK technology
DEVICEAmbulatory 24 hr Blood Pressure Monitoring
24 hr upper arm cuff measurement of Blood Pressure
PROCEDUREFundoscopy of eyes
examination of microvascular health of eye with the use of opthalmoscope
PROCEDURELaser Doppler Flowmetry
Examination of vascular flow
Sponsors
John Hunter Hospital
Study design
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
8 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* 8-18 years old * Have a diagnosis of type 1 diabetes mellitus
Exclusion criteria
* \< 8 years or \> 18 years old * Significant autoimmune rheumatological disease (e.g. lupus or dermatomyositis)
Countries
Australia
Outcome results
None listed