Metabonomics Fingerprinting of Multiple Trauma

Establishing 1H Nuclear Magnetic Resonance (NMR) Based Metabonomics Fingerprinting Profile for Severe Poly Trauma Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01279239

Enrollment

Registered

2011-01-19

Start date

2010-06-30

Completion date

2011-06-30

Last updated

2011-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trauma

Keywords

Poly Trauma, Metabonomics, NMR, MOF

Brief summary

The aim of this study is to establish plasma metabonomics fingerprinting atlas for severe multiple trauma patient using 1H nuclear magnetic resonance (NMR) based metabonomics methodology and advanced mathematics tools.

Detailed description

Metabonomics is a set of measurements of the dynamic metabolic responses of living systems to stimuli or modifications. This field of study developed from the application of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry as tools for the study of complex biofluids. Metabonomics is one of the emerging fields of systemic biology researches concerned with the high-throughput identification, quantification and characterization of small molecule metabolites. A metabonomics fingerprinting can be defined as the complete complement of all small molecule (\<1500 Da) metabolites found in a specific cell, body fluid, organ or organism. Severe poly trauma involves complex injuries that consist of multiple pathological mechanisms involving cytotoxic, oxidation stress and immune-endocrine. The complexity of the pathological physiology and biochemistry process are determined not only by the initial mechanical assault, but also by secondary processes including abnormality of inflammation regulation, ischemia, anoxia, free-radical formation, and immune dysfunction that occur over hours and days following the injury. For the clinical perspective, one of the key difficulties is to identify the most at-risk patients who could develop multiple organ failures and consequently death. This study aims to establish the dynamics of NMR-based metabonomics fingerprinting of severe multi-trauma patients in order to provide a possible multiple organs failure (MOF) or death event prediction.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Age:18-50 years * Poly trauma * Injury Severity Score (ISS)\>16 and Acute Physiology And Chronic Health Evaluation(APACHE)II\>10

Exclusion criteria

* With comorbidity (Diabetes,Hyperthyroidism or primary organ dysfunction ) * Pregnancy

Design outcomes

Primary

Measure	Time frame
Mortality at hospitalization	Death events from admission to discharge(up to 10 weeks)

Secondary

Measure	Time frame
Multi Organ Failure(MOF)	MOF events occurence from admission to discharge(up to 10 weeks)

Countries

China

Outcome results