Epilepsy
Conditions
Keywords
Epilepsy, Diet, the Modified Atkins Diet, Ketogenic diet
Brief summary
The purpose of the study is to evaluate the effect of the Modified Atkins Diet in children and adolescents with drug-resistant epilepsy regarding seizure control, and to create a protocol for the use of the Modified Atkins Diet as a treatment for epilepsy in Norway.
Detailed description
The study is a prospective trial on the Modified Atkins Diet for children and adolescents with drug-resistant epilepsy. The Modified Atkins Diet is a less restrictive diet than the classical ketogenic diet, which is usually offered to this group of patients. Twenty patients between 2 and 18 years are included in the study, and the study period is 6 months. The study will be conducted at the National Centre for Child Epilepsy in Norway.
Interventions
OTHERThe Modified Atkins Diet
The Modified Atkins Diet; 10 g carbohydrate per day and a high fat intake
Sponsors
Oslo University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* age: 2-18 years * At least 3 epileptic seizures per week * Tried at least two anti-epileptic drugs without satisfactory seizure control * Willing to try diet treatment for 6 months
Exclusion criteria
* Too difficult for the family to adhere to a strict diet * Not able to fill in a seizure calendar * Local authorities will not approve the treatment * VNS stimulator the last 12 months or changes made to VNS stimulator during the last three months * Other disease where a diet high in fat is contra indicated * Diet treatment is not possible because of poor intake of food or fluids * Cortisol or other medication that influence energy metabolism or epileptic drug metabolism last month * Patient has the last month used alternative medicine which may influence the diet * Patient has tried the ketogenic fiet og Modified Atkins diet the last three years * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Seizure frequency | 6 months | Seizure frequency is assessed after 1 month, 3 months and 6 months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ambulatory EEG | After 6 months | 24-hours EEG before diet treatment and after 6 months on the diet. |
| Body Weight | 6 months | Body weight was measured before diet treatment, after 1 month, 3 months and 6 months. |
| Quality of life | 6 months | Questionnaire assessing quality of life and life on a strict diet, assessed after one, three and six months. |
| Ketosis | 6 months | Ketosis in blood and urine measured during the whole study period |
| Dietary records | 10 weeks | 3-days dietary records were obtained after two and ten weeks on the diet. |
Countries
Norway
Outcome results
None listed