Complication of Hemodialysis
Conditions
Keywords
Renal failure, hemodialysis, dyslipidemia, L-carnitine.
Brief summary
The purpose of this study is to determine Effect of oral L-carnitine supplement on lipid profile, anemia, and quality of life.
Detailed description
In patients under maintenance hemodialysis several factors reduce the body stored carnitine which in turn affected dyslipidemia, anemia, and general health in these patients. The investigators evaluated the effect of oral L-carnitine supplementation on lipid profiles, anemia, and quality of life in hemodialysis patients.
Interventions
DRUGL-carnitine
500 mg,twice daily, 16 weeks
DRUGplacebo
500 mg,twice daily, 16 weeks.
Sponsors
Isfahan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
being in the age range of 18-75 having the history of at least 12 weeks of hemodialysis and at least three times a week and each session almost for four hours having serum triglyceride or total cholesterol concentration \>200 mg/dl or serum HDL concentration \>40 mg/dl in the beginning of the study.
Exclusion criteria
taking carnitine supplement or the drug that interact with carnation lowering the seizure threshold in the last month being affected by liver function abnormalities, hypothyroidism, chronic infectious diseases (such as hepatitis), inflammatory diseases, CNS mass having the history of seizure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lipid profile | at sixteen weeks after admission |
Secondary
| Measure | Time frame |
|---|---|
| anemia | at sixteen weeks after admission |
| quality of life | at sixteen weeks after admission |
Countries
Iran
Outcome results
None listed