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Ultrasound-image Guided Versus Doppler Guided Versus Palpation Technique for Arterial Cannulation in Adults

Ultrasound-image Guided Versus Doppler Guided Versus Palpation Technique for Arterial Cannulation in Adults

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01276171
Enrollment
749
Registered
2011-01-13
Start date
2010-02-28
Completion date
2015-04-30
Last updated
2017-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Brief summary

Radial arterial cannulation is a common invasive procedure for real-time measurement of arterial blood pressure. Placement of the arterial catheter using conventional palpation is often relatively easy and quick, but this is not always true. A relatively new method for direct visualization of the artery is the use of two-dimensional ultrasound. This technique allows cannulation of the artery to take place under real-time visualization and may increase the success rate of first time pass of the needle. Another technique utilizing Doppler has also proven to be effective in cannulating the radial artery. This technique utilizes changes in acoustic pitch as the probe passes directly over the artery. The primary objective of this study is to compare the first attempt success rate for radial artery cannulation among the palpation, Doppler and U/S guided technique when applied by trainees. Secondary outcomes include: success rate within 5 minutes, successful, number of attempts required, and correlation between success rate and operator experience for successful cannulation of the radial artery.

Detailed description

Radial artery cannulation is a common invasive procedure in the operating room, intensive care unit and emergency department. It allows continuous hemodynamic monitoring and repeated arterial blood sampling. Although severe complications are rare, successful radial artery cannulation can be technically challenging, particularly in hypotensive patients and those with vascular disease. Multiple unsuccessful attempts at arterial cannulation increase patient discomfort, delay timely care and may also contribute to adverse events such as arterial spasm or local hematoma. The radial artery is traditionally located by palpation. A number of techniques to aid radial artery localization have been described. Doppler-assisted radial arterial cannulation was first described in 1976. Several case reports suggest that Doppler can be helpful in patients with difficult arterial access. More recently, ultrasound-guided radial artery cannulation has been described. In a recent meta-analysis of four randomized controlled trials, ultrasound increased the rate of cannulation on the first attempt by 71% compared with palpation. However, two of the studies were of children and all four were small, with 30-152 participants (311 in total), making the generalizability of these results to adult patients uncertain. Furthermore, variation in the training and experience of the operators was evident within one of the studies. Accordingly, the aim of this study is to compare three different radial arterial cannulation techniques in adult surgical patients when performed by anesthesia residents: Doppler; palpation; and ultrasound. We think that ultrasound would have a higher rate of cannulation on the first attempt compared with other techniques.

Interventions

PROCEDUREPalpation

Participants will place arterial line using Palpation technique

PROCEDUREDoppler

Participants will place arterial line using doppler technique

PROCEDUREUltrasound

Participants will place arterial line using ultrasound technique

Sponsors

University of Iowa
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No

Inclusion criteria

* Main OR patients at UIHC who require arterial catheter placement for surgery

Exclusion criteria

* The patients who will be excluded from the study include those who have had arterial cannulation in the previous month, infections at site of insertion, and AV shunts in upper extremity.

Design outcomes

Primary

MeasureTime frameDescription
First Attempt Success Rate With 3 Different Technique5 minutesThe primary objective of this study is to compare the first attempt success rate for radial artery cannulation between the palpation, Doppler and U/S guided technique when applied by anesthesia trainees. Secondary outcomes include: success rate within 5 minutes, time to successful cannulation compared with three different techniques.

Secondary

MeasureTime frame
Time to Successful Cannulation5 minutes
Total Success Rate5 min

Countries

United States

Participant flow

Participants by arm

ArmCount
Ultrasound
Participants will place arterial line using ultrasound technique Ultrasound: Participants will place arterial line using ultrasound technique
249
Doppler
Participants will place arterial line using doppler technique Doppler: Participants will place arterial line using doppler technique
244
Palpation
Participants will place arterial line using palpation technique Palpation: Participants will place arterial line using Palpation technique
256
Total749

Baseline characteristics

CharacteristicDopplerPalpationUltrasoundTotal
Age, Categorical
<=18 years
0 Participants0 Participants0 Participants0 Participants
Age, Categorical
>=65 years
100 Participants99 Participants101 Participants300 Participants
Age, Categorical
Between 18 and 65 years
144 Participants157 Participants148 Participants449 Participants
Age, Continuous61 years59 years60 years60 years
Region of Enrollment
United States
244 participants256 participants249 participants749 participants
Sex: Female, Male
Female
107 Participants106 Participants106 Participants319 Participants
Sex: Female, Male
Male
137 Participants150 Participants143 Participants430 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
EG002
affected / at risk
deaths
Total, all-cause mortality
— / —— / —— / —
other
Total, other adverse events
27 / 24922 / 24429 / 256
serious
Total, serious adverse events
0 / 2490 / 2440 / 256

Outcome results

Primary

First Attempt Success Rate With 3 Different Technique

The primary objective of this study is to compare the first attempt success rate for radial artery cannulation between the palpation, Doppler and U/S guided technique when applied by anesthesia trainees. Secondary outcomes include: success rate within 5 minutes, time to successful cannulation compared with three different techniques.

Time frame: 5 minutes

ArmMeasureValue (NUMBER)
UltrasoundFirst Attempt Success Rate With 3 Different Technique132 participants
DopplerFirst Attempt Success Rate With 3 Different Technique101 participants
PalpationFirst Attempt Success Rate With 3 Different Technique96 participants
Secondary

Time to Successful Cannulation

Time frame: 5 minutes

ArmMeasureValue (MEDIAN)
UltrasoundTime to Successful Cannulation32 min
DopplerTime to Successful Cannulation118 min
PalpationTime to Successful Cannulation91 min
Secondary

Total Success Rate

Time frame: 5 min

Population: chi-squre test

ArmMeasureValue (COUNT_OF_PARTICIPANTS)
UltrasoundTotal Success Rate170 Participants
DopplerTotal Success Rate147 Participants
PalpationTotal Success Rate160 Participants

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026