New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01275963

Acronym

LAX

Enrollment

400

Registered

2011-01-13

Start date

2011-01-31

Completion date

2016-10-31

Last updated

2016-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Pathology

Keywords

Echocardiography, Strain imaging, Ventricular Dysfunction, Cardiomyopathy, Longitudinal left ventricular function

Brief summary

Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components. The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* persons of 18 years and older who receive a transthoracic echocardiography at our department * written consent

Exclusion criteria

* permanent pacemaker rhythm * moderate/severe valvular heart disease

Design outcomes

Primary

Measure	Time frame	Description
left ventricular longitudinal systolic strain (LV-LSS) in all patients	2 years	left ventricular longitudinal systolic strain (LV-LSS) is measured in all patients by speckle tracking strain imaging

Secondary

Measure	Time frame	Description
mitral annular plane systolic excursion (MAPSE) in all patients	2 years	MAPSE is measured by M-Mode echocardiography
mitral annular systolic velocity (MASV) in all patients	2 years	MASV is derived from tissue doppler
diastolic left ventricular function in all patients	2 years	Diastolic function is assesed by mitral inflow, mitral annulus velocity, pulmonary vein flow and velocity of flow progression.
pulmonary artery systolic pressure (PASP) in all patients	2 years	PASP is derived from Tricuspid valve regurgitation velocity
left ventricular ejection fraction (LVEF) in all patients	2 years	EF is measured by modified Simpson's rule (biplane)

Countries

Germany

Outcome results