Anal Incontinence
Conditions
Brief summary
The objectives of this work are: 1/to estimate the frequency of a positive glucose breath test in favour of a small intestinal bacterial overgrowth in a population of patients consulting for gaz incontinence by comparison to a population of control subjects; 2/to estimate versus a conventional treatment the efficiency of an antibiotic treatment; in case of small intestinal bacterial overgrowth diagnosed by the glucose breath test, to improve gaz incontinence
Interventions
DRUGMetronidazole
Metronidazole,per os,500mg, 3 per day during 10 days
DRUGCArbosylane
Sponsors
University Hospital, Rouen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Gaz incontinence for more than 3 months * Afflilied to national health security * Having read and sign the information letter and consent form
Exclusion criteria
* Pregnancy * use of antibiotics, probiotics, IPP for less tha n 3 months * past of small intestinal bacterial overgrowth * ischemic, inflammatory colitis,colo-rectal cancer * diabetes * allergy to metronidazole * psychiatric disease * patients who do not speak or read french
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of gaz incontinence episodes | 3 days before randomization and treatement and 3 days after 10 days of treatment (antibiotic or conventionnal treatment |
Countries
France
Outcome results
None listed