Developmental Disabilities
Conditions
Keywords
psychiatry, psychiatric illness, developmental disability, mental health, medication burden
Brief summary
There is no common rule as to how a drug will affect patients. This is due to the effect specific DNA sequences of genes have on drug response, by the effect they have on how medications are metabolized. The primary objective of this research is to optimize medication therapy and to reduce the number of medications used, specifically medications for people with developmental disabilities and co-occuring psychiatric illnesses.
Detailed description
The primary goal of this study is to develop a process for utilizing pharmacogenomic analysis as a strategy to improve the quality of life, safety, decrease medication burden, and enhance the effectiveness of medications in people with psychiatric illnesses and developmental disabilities. Ultimately, this inter-disciplinary service could be developed into a standard screening and consultation tool for healthcare providers to utilize when determining the most appropriate medication for their patients.
Interventions
GENETICGenetic analysis
The research team will review data following DNA sample analysis and identify variants in genes that result in impaired drug metabolism
Sponsors
Avera McKennan Hospital & University Health Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
13 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Current resident of the South Dakota Developmental Center (SDDC) * Currently taking a high number of medications per month * Eligibility of the subjects will be determined by the treatment team which consists of 3-4 of the following individuals: treating psychologist, behavior therapist, case manager, supervisors, counselors, dietitians, physician assistants, occupational therapists, and physical therapists
Exclusion criteria
* To be determined by the research staff
Outcome results
None listed