Gestational Diabetes Mellitus
Conditions
Keywords
Gestational diabetes mellitus, Meal test, Incretin hormones, Glucagon-like peptide-1 (GLP-1), Glucose-dependent insulinotropic polypeptide, Insulin, C-peptide, Glucagon
Brief summary
The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon. The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.
Detailed description
The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon. The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.
Interventions
OTHERMeal test
Liquid meal test
Sponsors
The Danish Diabetes Association
Aase and Ejnar Danielsens Foundation
The Novo Nordic Foundation
University Hospital, Gentofte, Copenhagen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Normal haemoblobin * Willingness to participate
Exclusion criteria
* First degree relative with diabetes * Diabetes before pregnancy * Positive islet cell- and GAD-65 autoantibodies
Countries
Denmark
Outcome results
None listed