Control of Elevated Eye Pressure by Local and Systemic Therapy
Conditions
Brief summary
Local therapy for glaucoma is known to induce a conjunctival inflammation. Because of this, trabeculectomy is more likely to fail. The investigators exchange the local therapy by systemic therapy using acetazolamide and measure the eye pressure using local therapy and systemic therapy using acetazolamide. The investigators suspect an elevated eye pressure using acetazolamide compared to local therapy. In summary acetazolamide could be a better choice in reference to conjunctival inflammation, but a worse choice in reference to controlling eye pressure.
Interventions
DRUGAcetazolamide for glaucoma patients to lower eye pressure
Acetazolamide tablets 3 times daily for 3 to 4 weeks
Sponsors
University of Cologne
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with uncontrolled intraocular eye pressure * Patients with planed trabeculectomy in 3 to 4 weeks
Exclusion criteria
* Patients not meeting the inclusion criteria * Patients with known intolerance to acetazolamide
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Eye pressure | Once at the beginning of the study and once 3 to 4 weeks later | The eye pressure is measured at the beginning of the study, when the patient is using the maximal tolerated local therapy and 3 to 4 weeks later, when using systemic acetazolamide treatment. |
Countries
Germany
Outcome results
None listed