Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia

Study of Effects of Cisatracurium and Atracurium on Intraocular Pressure

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01273831

Enrollment

Registered

2011-01-11

Start date

2009-07-31

Completion date

2009-12-31

Last updated

2011-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraocular Pressure

Keywords

intraocular pressure, anesthesia,cisatracurium,atracurium.

Brief summary

The purpose of this study is to determine which drug makes lower intraocular pressure

Detailed description

Increase in intraocular pressure (IOP) following tracheal intubation during general anesthesia can be troublesome. The investigators compared the influence of cisatracurium and atracurium on IOP in patients undergoing general anesthesia.

Interventions

DRUGatracurium

atracurium, Drop,0.5 mg/kg, one time, one day

DRUGcisatracurium

cisatracurium, drop,0.15mg/kg,one time, one day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

ASA class of I or II baseline IOP of lower than 20 mmHg stable hemodynamics no history of ophthalmic diseases not using drugs affecting IOP (e.g. anticholinergics, sympathomimetics) no contraindication for atracurium or cisatracurium administration.

Exclusion criteria

difficulty in mask ventilation or in tracheal intubation end expiratory CO2 of below 35 mmHg or over 45 mmHg O2 saturation of below 90%

Design outcomes

Primary

Measure	Time frame	Description
intraocular pressure	at 2 minutes after intubation	determining intraocular pressure in atracurium and cisatracurium groups

Secondary

Measure	Time frame	Description
systolic blood pressure	at 2 minutes after intubation	identification of systolic blood pressure in atracurium and cisatracurium groups

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026