Amphetamine Abuse, Amphetamine Dependence, Methamphetamine Abuse, Methamphetamine Dependence
Conditions
Keywords
amphetamine, methamphetamine, psychosocial intervention, contingency management, slow prosecution, substance use disorder
Brief summary
The hospital where this study will be conducted is responsible for the one-year contingency management treatment for methamphetamine drug offenders referred from the Yunlin District Prosecutors Office. Completing the one-year treatment is prerequisite for offenders to get slow prosecutions. It is an open-label, parallel-group trial comparing the combination of psychosocial intervention and slow prosecutions with psychosocial intervention alone in treating subjects with methamphetamine dependence Study Hypothesis 1. Psychosocial interventions in combination with slow prosecutions is more effective than psychosocial interventions alone to achieve abstinence for subjects with methamphetamine abuse/dependance. 2. Inclusion of telephone reminding before each visit will enhance the retention rate and abstinence rate.
Interventions
BEHAVIORALPsychosocial intervention
The treatment is one-year long and composed of 3 stages of psychosocial intervention. Subjects of TSTSU arms receive urine methamphetamine examinations at each visit, while subjects in OPD arm being tested at first/last visits and during stage changes. -Stage 1, early intensive monitoring stage: The visit interval is 1 week. If the urine tests and self-report on methamphetamine use are negative for consecutive 4 visits, subjects can proceed to stage 2. (In OPD arm, the visit interval can be 2 weeks according to subjects' requirements.) -Sage 2, late intensive monitoring stage: The visit interval is 2 week. If the urine tests and self-reports are straightly negative for 4 visits, subjects can proceed to stage 3. Whenever recent methamphetamine is detected, subjects should move back to stage 1. -Stage 3, usual monitoring stage: The visit interval is 1 month until the end of treatment. Whenever recent methamphetamine is detected, subjects should move back to stage 1.
BEHAVIORALTelephone reminding
Subjects in TSTSU-T group will receive addition telephone reminding one day before each visit. Each call will be no longer than five minutes. On the telephone, brief motivation enhancement may be conducted.
Sponsors
National Taiwan University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* DSM-IV-TR criteria for amphetamine/methamphetamine abuse or dependence * 18 - 65 years old * For TSTSU-N and TSTSU-T arms: methamphetamine offenders referred by the Yunlin District Prosecutors Office * For OPD arm: psychiatric outpatients referred from the psychiatry clinics in National Taiwan University Hospital, Yunlin Branch
Exclusion criteria
* Concurrent use of other illicit substances * Co-morbidity with major psychotic disorders (schizophrenia, schizoaffective disorder, other psychotic disorder), mental retardation, acute episodes of major depressive disorder or bipolar affective disorder) or serious personality disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endpoint abstinence rate | At the end of one-year treatment | According to the urine amphetamine/methamphetamine screen after the one-year treatment, negative result suggests successful abstinence. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Retention rate | during the whole one-year treatment | proportion of subjects who can complete the course of one-year treatment |
| Length of retention | during the whole one-year treatment | the averaged duration of attending treatment |
| The longest period of abstinence | during the whole one-year treatment | the longest period of time with successive negative results of urine amphetamine/methamphetamine tests or negative reports of recent methamphetamine use |
Countries
Taiwan
Contacts
Primary ContactYi-Ting Lin, M.D.
Outcome results
None listed