Kidney Stone, Oxidative Stress
Conditions
Keywords
pharmacokinetic, lime powder regimen, kidney stone, Oxidative stress
Brief summary
The study aims to investigate the pharmacokinetic parameters and its antioxidative effects in Thai healthy men.
Interventions
DIETARY_SUPPLEMENTLime powder regime
1 sachet of lime powder regimen with 200 ml of water
Sponsors
Chulalongkorn University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Thai healthy male or female aged 18-45 years old * BMI 18-25 kg/m2 * Normal medical history, physical examination and vital signs * Normal screening laboratories * no history of drug allergies * Willingness to take part in the study and provide informed consent
Exclusion criteria
* History of GI, liver, kidney, allergic disease or any other disease that may interfere with the bioavailability of lime powder regimen * History of alcohol or drug abuse * Heavy smoking * Receive any medication within 14 days prior to the study day
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The pharmacokinetic parameters of plasma and urine citrate | 6 months | The pharmacokinetic parameters of plasma and urine citrate incluiding Cmax, Tmax, Half life, AUC, and elimination rate constant |
Countries
Thailand
Outcome results
None listed