Carotid Stenosis, Hypoperfusion, Transient Ischemic Attack
Conditions
Brief summary
The carotid arteries are blood vessels in the neck that supply blood to the brain. Carotid stenosis disease is defined as a narrowing of these arteries due to the build up of plaque. The plaque material can also break off and move into the brain. The resulting blockage of blood supply to a portion of the brain is what causes 80% of all strokes. One treatment option is to have surgery on the carotid artery and remove the plaque. This procedure is called a carotid endarterectomy (CEA). There is evidence that proves CEA reduces the risk of stroke. The objective of this research project is to determine who is most likely to benefit from CEA surgery.
Interventions
None listed
Sponsors
Sunnybrook Health Sciences Centre
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Greater than 30 years of age * Greater than grade 9 education level * Mini-mental state exam (MMSE) greater than 19 for carotid stenosis patients
Exclusion criteria
* History of acute stroke * History of current psychiatric disorder, such as depression or movement disorder * Diagnosed Alzheimer's Disease or dementia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional MRI (fMRI) results will be used to calculate the activation-related hemodynamic response function (HRF) in patients undergoing carotid endarterectomy, which will be significantly reduced post-operative at 3 months follow-up. | Pre-operative, 3 months post-operative |
Secondary
| Measure | Time frame |
|---|---|
| Dynamic intracranial angiography will be correlated with arterial arrival time (AAT) hemodynamic metric calculated from arterial spin labeling (ASL) perfusion MRI. | Pre-operatively, 3 months post-operatively |
Countries
Canada
Contacts
Primary ContactBradley J MacIntosh, PhD
Outcome results
None listed