Coronary Artery Disease
Conditions
Brief summary
Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.
Interventions
OTHERexercise training
4 weeks supervised physical exercise training
Sponsors
German Research Foundation
Heart Center Leipzig - University Hospital
University of Leipzig
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* ≤ 75 years of age * stable coronary artery disease * preserved left ventricular function * physical work capacity of ≥ 50 * successful elective percutaneous coronary intervention at study begin
Exclusion criteria
* diabetes mellitus * hypercholesterolemia * untreated hypertension * smoking * myocardial infarction within the last 4 weeks * significant stenosis of the left main coronary artery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| migratory capacity of endothelial progenitor cells towards an SDF-1 gradient | 4 weeks |
Countries
Germany
Outcome results
None listed