Evaluation of Sloan-Charts for Assessment of Disease Progress in Multiple Sclerosis

Evaluation of Low Contrast Sloan Visual Charts as Method for the Assessment of Disease Progression in Multiple Sclerosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01272596

Enrollment

100

Registered

2011-01-10

Start date

2009-12-31

Completion date

2013-11-30

Last updated

2021-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis, Visual Contrast Acuity, Visual Contrast Sensitivity, Sloan Charts

Brief summary

Impairment of visual deficits, in particular contrast acuity and contrast impairment are frequent symptoms in MS. However, visual function is not appropriately covered by the standard tools for clinical assessment, namely, the EDSS and the MSFC. The primary aim of this study is to investigate, whether in MS patients contrast acuity and sensitivity change over a period of two years. Secondary aims are the correlation of visual contrast parameters with structural retinal changes and quality of life.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Clinically Isolated Syndrome or definite MS (relapsing-remitting or secondary progressive course) * Written Informed Consent

Exclusion criteria

* Relapse within the last 30 Days * Significant Cognitive Impairment * Severely Decreased Visual Acuity * Preexisting Severe Retinal Pathology

Design outcomes

Primary

Measure	Time frame
Visual Contrast Acuity	24 Months

Secondary

Measure	Time frame
Structural and Functional Changes of Optic Pathway	24 Months
Clinical Neurological Assessment	24 Months
Quality of Life	24 Months
Contrast Sensitivity	24 Months

Countries

Germany

Outcome results