Incorporating Avocados in Meals

Incorporating Avocados in Meals: Effect on Glycemic Index, Insulin Response, Satiety and Satiety-related Gastrointestinal Peptides in Humans

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01271829

Enrollment

Registered

2011-01-07

Start date

2011-01-31

Completion date

2012-09-30

Last updated

2014-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal Peptides and Hormones, Glycemic Index, Insulin, Satiety

Keywords

Avocados, Satiety, Feeding study

Brief summary

The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored. Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.

Interventions

DIETARY_SUPPLEMENTAvocado supplement

Calories from avocados replace calories of the control lunch

DIETARY_SUPPLEMENTAvocado included

Calories from avocados will be added to calories from the control lunch

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

23 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* 23-60 years old * BMI 23-32 * Stable weight for 6 months * Live or work near Loma Linda University

Exclusion criteria

* Smoker * Heavy involvement in sports * Dependent on caffeine

Design outcomes

Primary

Measure	Time frame	Description
Satiety	12 hours	The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode

Secondary

Measure	Time frame	Description
post-ingestion glycemic index	3 hours	Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. The glycemic index will be analyzed.
insulin response	3 hours	Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Insulin response will be analyzed.
appetite-related gastrointestinal peptide and hormone release	3 hours	Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Gastrointestinal peptide and hormones will be analyzed.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026