Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients

Observation of the Abnormal Potential From the Offending Vessel to the Facial Muscles of Hemifacial Spasm Patients

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01271634

Enrollment

Registered

2011-01-07

Start date

2011-01-31

Completion date

2011-12-31

Last updated

2011-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemifacial Spasm

Keywords

cross-transmission, offending vessel

Brief summary

The pathophysiologic basis of hemifacial spasm is cross-transmission between different branches of the facial nerve. The hypothesis is that the cross-transmission is mediated by the sympathetic nerve fibers on the surface of the offending artery. The abnormal potential from the offending vessel to the facial muscles will be detected on hemifacial spasm patients, so as to determine if the sympathetic nerve fibers take part in the circuit of cross-transmission.

Detailed description

It's hypothesized that at the location where the facial nerve is compressed by an artery, ephaptic cross-transmission takes place between the nude facial nerve fibers and the sympathetic nerve fibers on the arterial surface. Thus action potentials could spread indirectly from one facial nerve fiber to several other facial nerve fibers (via the bridge of sympathetic fibers), or directly from the sympathetic fibers to facial nerve fibers. The investigators assume this is the electrophysiological basis of hemifacial spasm and its characteristic sign abnormal muscle response (AMR). If an abnormal potential from the offending artery to the facial muscles similar to AMR can be recorded, the hypothesis will be verified.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

1. the age of 18-65 years old; 2. with typical hemifacial spasm symptoms; 3. with typical abnormal muscle response; 4. preoperative magnetic resonance imaging revealed obvious paraneural artery; 5. with informed consent.

Exclusion criteria

1. pregnant or lactating women; 2. accompanied by other serious diseases, including liver, kidney, cardiovascular diseases; 3. accompanied by mental illness or severe neurosis; 4. unable to express the subjective symptoms.

Design outcomes

Primary

Measure	Time frame
Abnormal Potential From the Offending Vessel to the Facial Muscles	up to 4 months

Secondary

Measure	Time frame
Latency from the root entry zone of facial nerve to the facial muscles	up to 4 months

Countries

China

Outcome results