Radiation Therapy, Coronary Artery Disease, Hodgkin Lymphoma
Conditions
Keywords
radiation therapy, coronary artery disease, Hodgkin Lymphoma
Brief summary
Survivors of Hodgkin Lymphoma (HL) are known to have an increased risk of developing late treatment sequelae such as cardiovascular events due to coronary artery disease. At present no active screening is performed in these patients since it is not known whether screening and subsequent treatment by means of revascularization is effective in reducing the risk of cardiovascular events in symptomatic individuals. In the trial the efficacy and therapeutic consequences of screening for coronary artery diasease by multi-slice CT (MSCT) among asymptomatic HL survivors will be evaluated.
Detailed description
Objectives: 1. to determine whether MSCT as a screening method of HL survivors treated with mediastinal irradiation accurately identifies asymptomatic significant coronary artery disease. 2. to establish the prevelance of coronary abnormalities in HL survivors treated with mediastinal irradiation 3. to determine the frequency and type of intervention 4. to evaluate the acceptance of screening and asses quality of life among Hl survivors. Study polulation: 50 long term survivors of HL, previously treatef with mediastinal irradiation without present evidence of cardiovascular disease Intervention: CT-coronary angiography and calcium score, to be performed as a screening method (to indicate further diagnostic treatent procedures)
Interventions
RADIATIONCT coronary angiography
patient will undergo one CT coronary angiography
Sponsors
Leiden University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* history of Hodgkin Lymphoma(all stages) with at least 10 disease free survival * current age between 35-60 * mediastinal irradiation as part of HL treatment, radiotherapy data available * written informed consent
Exclusion criteria
* current treatment for cardiovascualr disease, excelt hypertension hypercholesterolemia or cardiac murmurs * known or sypmtomatic heart failure * impaired kidney function (Cockcroft \< 55 ml/min) * known contrast allergy * invasive angiography in past 2 years * presence of life threatening disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| accurately identifying asymptomatic coronary artery disease | one year | to determine whether Ct coronary angiography as a screening method acuurately identifies asymptomatic coronary artery disease in a high risk poulation (HL survivors after mediastinal irradiation) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| prevalnce of cornary artery disease and frequency/type of subsequent intervention | one year | to establish the prevelence of coronary abnormalities in HL survivors treated with mediastinal irradiation, and to determine the frequency and type of subsequent interventions |
Countries
Netherlands
Outcome results
None listed