Bariatric Surgery Candidate, Diabetes Mellitus, Type 2
Conditions
Keywords
Resolvment of Diabetes Mellitus, Type 2, gastric bypass
Brief summary
Bariatric operations such as the gastric bypass procedure provide a unique in vivo model of improvement of pathological beta cell function. The presented double-centre study aims to comprehensively investigate different aspects of beta cell function in patients with type 2 diabetes (T2DM) with a wide range of disease duration after gastric bypass. In parallel, our project will address the aspects of changes in enteroinsular and adipoinsular axes as well as the early and late changes of other defined parameters after gastric bypass surgery.
Interventions
Sponsors
European Foundation for the Study of Diabetes
Medical University of Graz
Cantonal Hospital of St. Gallen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 18 years * indication forbariatric surgery or non-bariatric abdominal surgery
Exclusion criteria
* Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute insulin response (AIR) to glucose during IVGTT will be used as a primary variable characterizing the beta cell function | 10 days after gastric bypass |
Secondary
| Measure | Time frame |
|---|---|
| OGTT calculations and modelling describing beta cell response to oral glucose load; Insulin and C-peptide areas under the curve (AUCs) during OGTT quantifying the incretin effect. | 10 days after gastric bypass |
| • Plasma concentrations and adipose tissue expression of selected adipokines and inflammatory cytokines characterizing the adipoinsular axis | 10 days after gastric bypass |
Countries
Austria, Switzerland
Outcome results
None listed