Osteoarthritis of the Knee
Conditions
Keywords
Osteoarthritis, PRP, PRGF, Hyaluronic acid
Brief summary
Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. The aim is to examine the effect of a platelet-derived preparation rich in growth factors (PRGFs) in OA of the knee.
Detailed description
Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. The investigators aim is to examine the effect of a platelet-derived preparation rich in growth factors(PRGFs) in OA of the knee, using parameters of pain, function, quality of life and safety.
Interventions
BIOLOGICALPlatelet Rich Plasma (Preparation Rich in Growth Factors)
intra articular injection 6ml
DRUGHyaluronic acid
Intra articular injections: 20 mg / 2 ml
Sponsors
Meir Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* age 40-75 years old * diagnosed Oa of the knee more then 1 year * no knee deformation
Exclusion criteria
* mental of physical disabilities * pregnancy * deformities of the knee
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in pain, function, quality of life and activity level in knee osteoarthritis | 1 -2 years | Improvement in pain, function, quality of life, activity level - using scores adapted to measure these parameters in knee osteoarthritis. |
Countries
Israel
Contacts
Primary ContactLior Laver, MD
Outcome results
None listed