Bacterial Microbiota In The Tonsils Of Children

Bacterial Microbiota In The Tonsils Of Children Undergoing Adenotonsillectomy And Normal Controls

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01270243

Enrollment

Registered

2011-01-05

Start date

2010-12-01

Completion date

2017-02-18

Last updated

2023-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenotonsillitis

Brief summary

We, the investigators, propose to look at the bacteria on and in tonsils using gene microarrays. We expect to find previously reported bacteria but also the possibility of previously undetected organisms. We think that the bacterial pathogens present on the tonsillar surface are different from the tonsil core. And we also think that the bacteria of the tonsil surface will differ between patients undergoing adenotonsillectomy and normal controls with no adenotonsillar problems.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

2 Years to 12 Years

Healthy volunteers

Inclusion criteria

Inclusion criteria for subjects undergoing surgery: * Age 2-12 yrs * Both males and females * Undergoing adenotonsillectomy Additional criteria for subjects in the recurrent infection group: * Sleep questionnaire score \<5 * Designated by surgeon as having recurrent adenotonsillitis as reason for surgery Additional criteria for subjects in the airway obstruction group: * Sleep questionnaire score \>5 * Presence of positive polysomnogram desired but not necessary * Designated by surgeon as having airway obstruction or sleep apnea as reason for surgery Inclusion criteria for control subjects: * Age 2-12 yrs * Both males and females * No history of adenotonsillar problems * Sleep questionnaire score \< 5

Countries

United States

Outcome results