Aspirin, Coronary Artery Disease, Off-pump Coronary Artery Bypass
Conditions
Keywords
coronary artery disease, off-pump coronary artery bypass, aspirin
Brief summary
Antiplatelet therapy is critical in the management of coronary artery disease.For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.And there is little study about the effect of continuing aspirin until the surgery day on graft patency.So we would like to perform this study to evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary bypass.
Interventions
DRUGaspirin
aspirin 100mg daily until the surgery day
Sponsors
Chinese Academy of Medical Sciences, Fuwai Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing elective, off-pump coronary artery bypass with at least two grafts * patient able to give informed consent
Exclusion criteria
* on-pump CABG * combined with the valve surgery * Preoperative use of clopidogrel and warfarin * allergy to aspirin * History of severe liver disease * History of bleeding diathesis,significant GI bleed * Patient has known renal failure or contraindication for Cardiac CT Angio * Redo CABG
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| graft patency examined by CT scan | one week after surgery | we would like to compare the graft patency within the one week after the surgery between the preoperative aspirin use and preoperative nonuse.We just want to know wether preoperative aspirin use could improve the graft patency in off-pump coronary artery bypass. |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding, transfusion, re-exploration | perioperative |
Countries
China
Outcome results
None listed