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Effect of Doxepin and Nortriptyline on Irritable Bowel Syndrome

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01268709
Enrollment
Unknown
Registered
2010-12-31
Start date
Unknown
Completion date
Unknown
Last updated
2010-12-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome

Brief summary

The objective of this randomized triple blind controlled trial is to compare the effects of Doxepin and Nortriptyline on diarrhea predominant irritable bowel syndrome. In this stuy, 75 patients with IBS are randomly assigned to receive Doxepin , Nortriptyline or placebo, a tablet per day, orally, for two months. Abdominal pain, mucus in the stool, incomplete evacuation, and bloating are measured and compared between groups at the baseline and one and two month after the intervention.

Interventions

DRUGDoxepin
DRUGNortriptyline
DRUGplacebo

Sponsors

Young Researchers Club
CollaboratorUNKNOWN
Qom University of Medical Sciences
Lead SponsorOTHER

Study design

Primary purpose
TREATMENT

Eligibility

Sex/Gender
ALL

Inclusion criteria

* Presence of diarrhea predominant irritable bowel syndrome according to ROME criteria

Exclusion criteria

* Gastrointestinal bleeding * More than 5% weight loss in the last 6 months * Presence of any finding in favor of organic disorders in the lab tests or organic disorder in colonoscopy of high risk patients

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026